LOCUS       HUMIL1BX     9721 bp ds-DNA              PRI       15-JUN-1988
DEFINITION  Human interleukin 1 beta gene.
ACCESSION   X04500
SOURCE  
  ORGANISM  Homo sapiens
REFERENCE   1
  AUTHOR    Clark,B.D., Collins,K.L., Gandy,M.S., Webb,A.C. and Auron,P.E.
  JOURNAL   Nucleic Acids Res. 14, 7897-7914 (1986)
 STANDARD   simple    
FEATURES       from  to/span     description
    pept       2481     2527     prointerleukin-1-beta, exon 2 ( first
                                 expressed exon) /nomgen="IL1"
                                 /map="2q13-q21"
               3092     3143     prointerleukin-1-beta, exon 3
               5125     5326     prointerleukin-1-beta, exon 4
               5874     6038     prointerleukin-1-beta, exon 5
               7275     7405     prointerleukin-1-beta, exon 6
               8127     8339     prointerleukin-1-beta, exon 7
    pre-msg    1934     8941     IL mRNA and introns
    IVS        2006     2465     IL intron A
    IVS        2528     3091     IL intron B
    IVS        3144     5124     IL intron C
    IVS        5327     5873     IL intron D
    IVS        6039     7274     IL intron E
    IVS        7406     8126     IL intron F
    rpt         656      668     Alu repeat copy A 5' flank
    rpt         669      960     Alu repeat copy A
    rpt         961      971     Alu repeat copy A 3' flank
    rpt        4642     4658     Alu repeat copy B 5' flank
    rpt        4659     4988     Alu repeat copy B
    rpt        4989     5007     Alu repeat copy B 3' flank
    rpt        9251     9721     Alu repeat copy C
    refnumbr   1934     1934     numbered 1 in [1]; zero not used
BASE COUNT     2661 a   2328 c   2122 g   2608 t      2 others
ORIGIN
        1 agaaagaaag agagagagaa agaaaagaaa gaggaaggaa ggaaggaagg aagaaagaca 
       61 ggctctgagg aaggtggcag ttcctacaac gggagaacca gtggttaatt tgcaaagtgg 
      121 atcctgtgga ggcanncaga ggagtcccct aggccaccca gacagggctt ttagctatct 
      181 gcaggccaga caccaaattt caggagggct cagtgttagg aatggattat ggcttatcaa 
      241 attcacagga aactaacatg ttgaacagct tttagatttc ctgtggaaaa tataacttac 
      301 taaagatgga gttcttgtga ctgactcctg atatcaagat actgggagcc aaattaaaaa 
      361 tcagaaggct gcttggagag caagtccatg aaatgctctt tttcccacag tagaacctat 
      421 ttccctcgtg tctcaaatac ttgcacagag gctcactccc ttggataatg cagagcgagc 
      481 acgatacctg gcacatacta atttgaataa aatgctgtca aattcccatt cacccattca 
      541 agcagcaaac tctatctcac ctgaatgtac atgccaggca ctgtgctaga cttggctcaa 
      601 aaagatttca gtttcctgga ggaaccagga gggcaaggtt tcaactcagt gctataagaa 
      661 gtgttacagg ctggacacgg tggctcacgc ctgtaatccc aacatttggg aggccgaggc 
      721 gggcagatca caaggtcagg agatcgagac catcctggct aacatggtga aaccctgtct 
      781 ctactaaaaa tacaaaaaat tagccgggcg ttggcggcag gtgcctgtag tcccagctgc 
      841 tggggaggct gaggcaggag aatggtgtga acccgggagg cggaacttgc agggggccga 
      901 gatcgtgcca ctgcactcca gcctgggcga cagagtgaga ctctgtctca aaaaaaaaaa 
      961 aaaagtgtta tgatgcagac ctgtcaaaga ggcaaaggag ggtgttccta cactccaggc 
     1021 actgttcata acctggactc tcattcattc tacaaatgga gggctcccct gggcagatcc 
     1081 ctggagcagg cactttgctg gtgtctcggt taaagagaaa ctgataactc ttggtattac 
     1141 caagagatag agtctcagat ggatattctt acagaaacaa tattcccact tttcagagtt 
     1201 caccaaaaaa tcattttagg cagagctcat ctggcattga tctggttcat ccatgagatt 
     1261 ggctagggta acagcacctg gtcttgcagg gttgtgtgag cttatctcca gggttgcccc 
     1321 aactccgtca ggagcctgaa ccctgcatac cgtatgttct ctgccccagc caagaaaggt 
     1381 caattttctc ctcagaggct cctgcaattg acagagagct cccgaggcag agaacagcac 
     1441 ccaaggtaga gacccacacc ctcaatacag acagggaggg ctattggccc ttcattgtac 
     1501 ccatttatcc atctgtaagt gggaagattc ctaaacttaa gtacaaagaa gtgaatgaag 
     1561 aaaagtatgt gcatgtataa atctgtgtgt cttccacttt gtcccacata tactaaattt 
     1621 aaacattctt ctaacgtggg aaaatccagt attttaatgt ggacatcaac tgcacaacga 
     1681 ttgtcaggaa aacaatgcat atttgcatgg tgatacattt gcaaaatgtg tcatagtttg 
     1741 ctactccttg cccttccatg aaccagagaa ttatctcagt ttattagtcc cctcccctaa 
     1801 gaagcttcca ccaatactct tttccccttt cctttaactt gattgtgaaa tcaggtattc 
     1861 aacagagaaa tttctcagcc tcctacttct gcttttgaaa gctataaaaa cagcgaggga 
     1921 gaaactggca gataccaaac ctcttcgagg cacaaggcac aacaggctgc tctgggattc 
     1981 tcttcagcca atcttcattg ctcaagtatg actttaatct tccttacaac taggtgctaa 
     2041 gggagtctct ctgtctctct gcctctttgt gtgtatgcat attctctctc tctctctctt 
     2101 tctttctctg tctctcctct ccttcctctc tgcctcctct ctcagctttt tgcaaaaatg 
     2161 ccaggtgtaa tataatgctt atgactcggg aaatattctg ggaatggata ctgcttatct 
     2221 aacagctgac accctaaagg ttagtgtcaa agcctctgct ccagctctcc tagccaatac 
     2281 attgctagtt ggggtttggt ttagcaaatg cttttctcta gacccaaagg acttctcttt 
     2341 cacacattca ttcatttact cagagatcat ttctttgcat gactgccatg cactggatgc 
     2401 tgagagaaat cacacatgaa cgtagccgtc atggggaagt cactcatttt ctccttttta 
     2461 cacaggtgtc tgaagcagcc atggcagaag tacctgagct cgccagtgaa atgatggctt 
     2521 attacaggtc agtggagacg ctgagaccag taacatgagc aggtctcctc tttcaagagt 
     2581 agagtgttat ctgtgcttgg agaccagatt tttcccctaa attgcctctt tcagtggcaa 
     2641 acagggtgcc aagtaaatct gatttaaaga ctactttccc attacaagtc cctccagcct 
     2701 tgggacctgg aggctatcca gatgtgttgt tgcaagggct tcctgcagag gcaaatgggg 
     2761 agaaaagatt ccaagcccac aatacaagga atccctttgc aaagtgtggc ttggagggag 
     2821 agggagagct cagattttag ctgactctgc tgggctagag gttaggcctc aagatccaac 
     2881 agggagcacc agggtgccca cctgccaggc ctagaatctg ccttctggac tgttctgcgc 
     2941 atatcactgt gaaacttgcc aggtgtttca ggcagctttg agaggcaggc tgtttgcagt 
     3001 ttcttatgaa cagtcaagtc ttgtacacag ggaaggaaaa ataaacctgt ttagaagaca 
     3061 taattgagac atgtccctgt ttttattaca gtggcaatga ggatgacttg ttctttgaag 
     3121 ctgatggccc taaacagatg aaggtaagac tatgggttta actcccaacc caaggaaggg 
     3181 ctctaacaca gggaaagctc aaagaaggga gttctgggcc actttgatgc catggtattt 
     3241 tgttttagaa agactttaac ctcttccagt gagacacagg ctgcaccact tgctgacctg 
     3301 gccacttggt catcatatca ccacagtcac tcactaacgt tggtggtggt ggccacactt 
     3361 ggtggtgaca ggggaggagt agtgataatg ttcccatttc atagtaggaa gacaaccaag 
     3421 tcttcaacat aaatttgatt atccttttaa gagatggatt cagcctatgc caatcacttg 
     3481 agttaaactc tgaaaccaag agatgatctt gagaactaac atatgtctac cccttttgag 
     3541 tagaatagtt ttttgctacc tggggtgaag cttataacaa caagacatag atgatataaa 
     3601 caaaaagatg aattgagact tgaaagaaaa ccattcactt gctgtttgac cttgacaagt 
     3661 cattttaccc gctttggacc tcatctgaaa aataaagggc tgagctggat gatctctgag 
     3721 attccagcat cctgcaacct ccagttctga aatattttca gttgtagcta agggcatttg 
     3781 ggcagcaaat ggtcattttt cagactcatc cttacaaaga gccatgttat attcctgctg 
     3841 tcccttctgt tttatatgat gctcagtagc cttcctaggt gcccagccat cagcctagct 
     3901 aggtcagttg tgcaggttgg aggcagccac ttttctctgg ctttatttta ttccagtttg 
     3961 tgatagcctc ccctagcctc ataatccagt cctcaatctt gttaaaaaca tatttcttta 
     4021 gaagttttaa gactggcata acttcttggc tgcagctgtg ggaggagccc attggcttgt 
     4081 ctgcctggcc tttgcccccc attgcctctt ccagcagctt ggctctgctc caggcaggaa 
     4141 attctctcct gctcaacttt cttttgtgca cttacaggtc tctttaactg tctttcaagc 
     4201 ctttgaacca ttatcagcct taaggcaacc tcagtgaagc cttaatacgg agcttctctg 
     4261 aataagagga aagtggtaac atttcacaaa aagtactctc acaggatttg cagaatgcct 
     4321 atgagacagt gttatgaaaa aggaaaaaaa agaacagtgt agaaaaattg aatacttgct 
     4381 gagtgagcat aggtgaatgg aaaatgttat ggtcatctgc atgaaaaagc aaatcatagt 
     4441 gtgacagcat tagggataca aaaagatata gagaaggtat acatgtatgg tgtaggtggg 
     4501 gcatgtacaa aaagatgaca agtagaatcg ggatttattc taaagaatag cctgtaaggt 
     4561 gtccagaagc cacattctag tcttgagtct gcctctacct gctgtgtgcc cttgagtaca 
     4621 cccttaacct ccttgagctt cagagaggga taatcttttt attttatttt attttatttt 
     4681 gttttgtttt gttttgtttt gttttatgag acagagtctc actctgttgc ccaggctgga 
     4741 gtgcagtggt acaatcttgg cttactgcat cctccacctc ctgagttcaa gcgattctcc 
     4801 ttcctcagtc tcctgaatag ctaggattac aggtgcaccc caccacaccc agctaatttt 
     4861 tgtattttta gtagagaagg ggtttcgcca tgttggccag gctggttttg aagtcctgac 
     4921 ctaaatgatt catccacctc ggcttcccaa agtgctggga ttacaggcat gagccaccac 
     4981 gcctggccca gagagggatg atctttagaa gctcgggatt ctttcaagcc ctttcctcct 
     5041 ctctgagctt tctactctct gatgtcaaag catggttcct ggcaggacca cctcaccagg 
     5101 ctccctccct cgctctctcc gcagtgctcc ttccaggacc tggacctctg ccctctggat 
     5161 ggcggcatcc agctacgaat ctccgaccac cactacagca agggcttcag gcaggccgcg 
     5221 tcagttgttg tggccatgga caagctgagg aagatgctgg ttccctgccc acagaccttc 
     5281 caggagaatg acctgagcac cttctttccc ttcatctttg aagaaggtag ttagccaaga 
     5341 gcaggcagta gatctccact tgtgtcctct tggaagtcat caagccccag ccaactcaat 
     5401 tcccccagag ccaaagccct ttaaaggtag aaggcccagc ggggagacaa aacaaagaag 
     5461 gctggaaacc aaagcaatca tctctttagt ggaaactatt cttaaagaag atcttgatgg 
     5521 ctactgacat ttgcaactcc ctcactcttt ctcaggggcc tttcacttac attgtcacca 
     5581 gaggttcgta acctccctgt gggctagtgt tatgaccatc accattttac ctaagtagct 
     5641 ctgttgctcg gccacagtga gcagtaatag acctgaagct ggaacccatg tctaatagtg 
     5701 tcaggtccag tgttcttagc caccccactc ccagcttcat ccctactggt gttgtcatca 
     5761 gactttgacc gtatatgctc aggtgtcctc caagaaatca aattttgcca cctcgcctca 
     5821 cgaggcctgc ccttctgatt ttatacctaa acaacatgtg ctccacattt cagaacctat 
     5881 cttcttcgac acatgggata acgaggctta tgtgcacgat gcacctgtac gatcactgaa 
     5941 ctgcacgctc cgggactcac agcaaaaaag cttggtgatg tctggtccat atgaactgaa 
     6001 agctctccac ctccagggac aggatatgga gcaacaaggt aaatggaaac atcctggttt 
     6061 ccctgcctgg cctcctggca gcttgctaat tctccatgtt ttaaacaaag tagaaagtta 
     6121 atttaaggca aatgatcaac acaagtgaaa aaaaatatta aaaaggaata tacaaacttt 
     6181 ggtcctagaa atggcacatt tgattgcact ggccagtgca tttgttaaca ggagtgtgac 
     6241 cctgagaaat tagacggctc aagcactccc aggaccatgt ccacccaagt ctcttgggca 
     6301 tagtgcagtg tcaattcttc cacaatatgg ggtcatttga tggacatggc ctaactgcct 
     6361 gtgggttctc tcttcctgtt gttgaggctg aaacaagagt gctggagcga taatgtgtcc 
     6421 atccccctcc ccagtcttcc ccccttgccc caacatccgt cccacccaat gccaggtggt 
     6481 tccttgtagg gaaattttac cgcccagcag gaacttatat ctctccgctg taacgggcaa 
     6541 aagtttcaag tgcggtgaac ccatcattag ctgtggtgat ctgcctggca tcgtgccaca 
     6601 gtagccaaag cctctgcaca ggagtgtggg caactaaggc tgctgacttt gaaggacagc 
     6661 ctcactcagg gggaagctat ttgctctcag ccaggccaag aaaatcctgt ttctttggaa 
     6721 tcgggtagta agagtgatcc cagggcctcc aattgacact gctgtgactg aggaagatca 
     6781 aaatgagtgt ctctctttgg agccactttc ccagctcagc ctctcctctc ccagtttctt 
     6841 cccatgggct actctctgtt cctgaaacag ttctggtgcc tgatttctgg cagaagtaca 
     6901 gcttcacctc tttcctttcc ttccacattg atcaagttgt tccgctcctg tggatgggca 
     6961 cattgccagc cagtgacaca atggcttcct tccttccttc cttcagcatt taaaatgtag 
     7021 accctctttc attctccgtt cctactgcta tgaggctctg agaaaccctc aggcctttga 
     7081 ggggaaaccc taaatcaaca aaatgaccct gctattgtct gtgagaagtc aagttatcct 
     7141 gtgtcttagg ccaaggaacc tcactgtggg ttcccacaga ggctaccaat tacatgtatc 
     7201 ctactctcgg ggctaggggt tggggtgacc ctgcatgctg tgtccctaac cacaagaccc 
     7261 ccttctttct tcagtggtgt tctccatgtc ctttgtacaa ggagaagaaa gtaatgacaa 
     7321 aatacctgtg gccttgggcc tcaaggaaaa gaatctgtac ctgtcctgcg tgttgaaaga 
     7381 tgataagccc actctacagc tggaggtaag tgaatgctat ggaatgaagc ccttctcagc 
     7441 ctcctgctac cacttattcc cagacaattc accttctccc cgcccccatc cctaggaaaa 
     7501 gctgggaaca ggtctatttg acaagttttg cattaatgta aataaattta acataatttt 
     7561 taactgcgtg caaccttcaa tcctgctgca gaaaattaaa tcattttgcc gatgttatta 
     7621 tgtcctacca tagttacaac cccaacagat tatatattgt tagggctgct ctcatttgat 
     7681 agacaccttg ggaaatagat gacttaaagg gtcccattat cacgtccact ccactcccaa 
     7741 aatcaccacc actatcacct ccagctttct cagcaaaagc ttcatttcca agttgatgtc 
     7801 attctaggac cataaggaaa aatacaataa aaagcccctg gaaactaggt acttcaagaa 
     7861 gctctagctt aattttcacc cccccaaaaa aaaaaaattc tcacctacat tatgctcctc 
     7921 agcatttggc actaagtttt agaaaagaag aagggctctt ttaataatca cacagaaagt 
     7981 tgggggccca gttacaactc aggagtctgg ctcctgatca tgtgacctgc tcgtcagttt 
     8041 cctttctggc caacccaaag aacatctttc ccataggcat ctttgtccct tgccccacaa 
     8101 aaattcttct ttctctttcg ctgcagagtg tagatcccaa aaattaccca aagaagaaga 
     8161 tggaaaagcg atttgtcttc aacaagatag aaatcaataa caagctggaa tttgagtctg 
     8221 cccagttccc caactggtac atcagcacct ctcaagcaga aaacatgccc gtcttcctgg 
     8281 gagggaccaa aggcggccag gatataactg acttcaccat gcaatttgtg tcttcctaaa 
     8341 gagagctgta cccagagagt cctgtgctga atgtggactc aatccctagg gctggcagaa 
     8401 agggaacaga aaggtttttg agtacggcta tagcctggac tttcctgttg tctacaccaa 
     8461 tgcccaactg cctgccttag ggtagtgcta agaggatctc ctgtccatca gccaggacag 
     8521 tcagctctct cctttcaggg ccaatcccca gcccttttgt tgagccaggc ctctctcacc 
     8581 tctcctactc acttaaagcc cgcctgacag aaaccacggc cacatttggt tctaagaaac 
     8641 cctctgtcat tcgctcccac attctgatga gcaaccgctt ccctatttat ttatttattt 
     8701 gtttgtttgt tttgattcat tggtctaatt tattcaaagg gggcaagaag tagcagtgtc 
     8761 tgtaaaagag cctagttttt aatagctatg gaatcaattc aatttggact ggtgtgctct 
     8821 ctttaaatca agtcctttaa ttaagactga aaatatataa gctcagatta tttaaatggg 
     8881 aatatttata aatgagcaaa tatcatactg ttcaatggtt ctgaaataaa cttcactgaa 
     8941 gaaaaaaaaa aaagggtctc tcctgatcat tgactgtctg gattgacact gacagtaagc 
     9001 aaacaggctg tgagagttct tgggactaag cccactcctc attgctgagt gctgcaagta 
     9061 cctagaaata tccttggcca ccgaagacta tcctcctcac ccatcccctt tatttcgttg 
     9121 ttcaacagaa ggatattcag tgcacatctg gaacaggatc agctgaagca ctgcagggag 
     9181 tcaggactgg tagtaacagc taccatgatt tatctatcaa tgcaccaaac atctgttgag 
     9241 caagcgctat gtactaggag ctgggagtac agagatgaga acagtcacaa gtccctcctc 
     9301 agataggaga ggcagctagt tataagcaga acaaggtaac atgacaagta gagtaagata 
     9361 gaagaacgaa gaggagtagc caggaaggag ggaggagaac gacataagaa tcaagcctaa 
     9421 agggataaac agaagatttc cacacatggg ctgggccaat tgggtgtcgg ttacgcctgt 
     9481 aatcccagca ctttgggtgg caggggcaga aagatcgctt gagcccagga gttcaagacc 
     9541 agcctgggca acatagtgag actcccatct ctacaaaaaa taaataaata aataaaacaa 
     9601 tcagccaggc atgctggcat gcacctgtag tcctagctac ttgggaagct gacactggag 
     9661 gattgcttga gcccagaagt tcaagactgc agtgagctta tccgttgacc tgcaggtcga 
     9721 c
//
